6,739 research outputs found
HESS J1825-137: A pulsar wind nebula associated with PSR B1823-13?
HESS J1825-137 was detected with a significance of 8.1 in the
Galactic Plane survey conducted with the H.E.S.S. instrument in 2004. Both HESS
J1825-137 and the X-ray pulsar wind nebula G18.0--0.7 (associated with the
Vela-like pulsar PSR B1823-13) are offset south of the pulsar, which may be the
result of the SNR expanding into an inhomogeneous medium. The TeV size ( pc, for a distance of 4 kpc) is times larger than the X-ray size,
which may be the result of propagation effects as a result of the longer
lifetime of TeV emitting electrons, compared to the relatively short lifetime
of keV synchrotron emitting electrons. The TeV photon spectral index of can also be related to the extended PWN X-ray synchrotron photon index of
, if this spectrum is dominated by synchrotron cooling. The
anomalously large size of the pulsar wind nebula can be explained if the pulsar
was born with a relatively large initial spindown power and braking index
, provided that the SNR expanded into the hot ISM with relatively low
density ( cm).Comment: 4 pages, 4 figures, to appear in the Proc. of the 29th International
Cosmic Ray Conference, OG Sessio
The GeV-TeV Connection in Galactic gamma-ray sources
Recent observations with atmospheric Cherenkov telescope systems such as
H.E.S.S. and MAGIC have revealed a large number of new sources of
very-high-energy (VHE) gamma-rays from 100 GeV - 100 TeV, mostly concentrated
along the Galactic plane. At lower energies (100 MeV - 10 GeV) the
satellite-based instrument EGRET revealed a population of sources clustering
along the Galactic Plane. Given their adjacent energy bands a systematic
correlation study between the two source catalogues seems appropriate. Here,
the populations of Galactic sources in both energy domains are characterised on
observational as well as on phenomenological grounds. Surprisingly few common
sources are found in terms of positional coincidence and spectral consistency.
These common sources and their potential counterparts and emission mechanisms
will be discussed in detail. In cases of detection only in one energy band, for
the first time consistent upper limits in the other energy band have been
derived. The EGRET upper limits are rather unconstraining due to the
sensitivity mismatch to current VHE instruments. The VHE upper limits put
strong constraints on simple power-law extrapolation of several of the EGRET
spectra and thus strongly suggest cutoffs in the unexplored energy range from
10 GeV - 100 GeV. Physical reasons for the existence of cutoffs and for
differences in the source population at GeV and TeV energies will be discussed.
Finally, predictions will be derived for common GeV - TeV sources for the
upcoming GLAST mission bridging for the first time the energy gap between
current GeV and TeV instruments.Comment: (1) Kavli Institute for Particle Astrophysics and Cosmology (KIPAC),
Stanford, USA (2) Stanford University, W.W. Hansen Experimental Physics Lab
(HEPL) and KIPAC, Stanford, USA (3) ICREA & Institut de Ciencies de l'Espai
(IEEC-CSIC) Campus UAB, Fac. de Ciencies, Barcelona, Spain. (4) School of
Physics and Astronomy, University of Leeds, UK. Paper Submitted to Ap
XMM-Newton observations of HESS J1813-178 reveal a composite Supernova remnant
We present X-ray and 12CO(J=1-0) observations of the very-high-energy (VHE)
gamma-ray source HESS J1813-178 with the aim of understanding the origin of the
gamma-ray emission. Using this dataset we are able to undertake spectral and
morphological studies of the X-ray emission from this object with greater
precision than previous studies. NANTEN 12CO(J=1-0) data are used to search for
correlations of the gamma-ray emission with molecular clouds which could act as
target material for gamma-ray production in a hadronic scenario. The NANTEN
12CO(J=1-0) observations show a giant molecular cloud of mass 2.5 10^5
M_{\sun} at a distance of 4 kpc in the vicinity of HESS J1813-178. Even
though there is no direct positional coincidence, this giant cloud might have
influenced the evolution of the gamma-ray source and its surroundings. The
X-ray data show a highly absorbed non-thermal X-ray emitting object coincident
with the previously known ASCA source AX J1813-178 showing a compact core and
an extended tail towards the north-east, located in the centre of the radio
shell-type Supernova remnant (SNR) G12.82-0.2. This central object shows
morphological and spectral resemblance to a Pulsar Wind Nebula (PWN) and we
therefore consider that the object is very likely to be a composite SNR. We
discuss the scenario in which the gamma-rays originate in the shell of the SNR
and the one in which they originate in the central object. We demonstrate, that
in order to connect the core X-ray emission to the VHE gamma-ray emission
electrons have to be accelerated to energies of at least 1 PeV.Comment: Submitted to A&
A search for VHE counterparts of Galactic Fermi bright sources and MeV to TeV spectral characterization
Very high-energy (VHE; E>100 GeV) gamma-rays have been detected from a wide
range of astronomical objects, such as pulsar wind nebulae (PWNe), supernova
remnants (SNRs), giant molecular clouds, gamma-ray binaries, the Galactic
Center, active galactic nuclei (AGN), radio galaxies, starburst galaxies, and
possibly star-forming regions as well. At lower energies, observations using
the Large Area Telescope (LAT) onboard Fermi provide a rich set of data which
can be used to study the behavior of cosmic accelerators in the MeV to TeV
energy bands. In particular, the improved angular resolution of current
telescopes in both bands compared to previous instruments significantly reduces
source confusion and facilitates the identification of associated counterparts
at lower energies. In this paper, a comprehensive search for VHE gamma-ray
sources which are spatially coincident with Galactic Fermi/LAT bright sources
is performed, and the available MeV to TeV spectra of coincident sources are
compared. It is found that bright LAT GeV sources are correlated with TeV
sources, in contrast to previous studies using EGRET data. Moreover, a single
spectral component seems unable to describe the MeV to TeV spectra of many
coincident GeV/TeV sources. It has been suggested that gamma-ray pulsars may be
accompanied by VHE gamma-ray emitting nebulae, a hypothesis that can be tested
with VHE observations of these pulsars.Comment: Astronomy and Astrophysics, in press, 17 pages, 12 figures, 5 table
Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
p21 inhibits cyclin-dependent kinase (CDK) activity and proliferating cell nuclear antigen (PCNA)-dependent DNA replication by binding to CDK/cyclin complexes and to PCNA through distinct domains. The human papillomavirus (HPV)-16 E7 oncoprotein (16E7) abrogated a DNA damage-induced cell cycle arrest in vivo, despite high levels of p21. Using cell lysates and purified proteins we show that 16E7 prevented p21 both from inhibiting CDK2/cyclin E activity and PCNA-dependent DNA replication, whereas the nononcogenic HPV-6 E7 had reduced effects. Inactivation of both inhibitory functions of p21 was attained through binding between 16E7 and sequences in the carboxy-terminal end of p21 that overlap with the PCNA-binding site and the second p21 cyclin-binding motif. These data imply that the carboxyl terminus of p21 simultaneously modulates both CDK activity and PCNA-dependent DNA replication and that a single protein, 16E7, can override this modulation to disrupt normal cell cycle control
A multiple scale model for tumor growth
We present a physiologically structured lattice model for vascular tumor growth which accounts for blood flow and structural adaptation of the vasculature, transport of oxygen, interaction between cancerous and normal tissue, cell division, apoptosis, vascular endothelial growth factor release, and the coupling between these processes. Simulations of the model are used to investigate the effects of nutrient heterogeneity, growth and invasion of cancerous tissue, and emergent growth laws
Kinetic approaches to particle acceleration at cosmic ray modified shocks
Kinetic approaches provide an effective description of the process of
particle acceleration at shock fronts and allow to take into account the
dynamical reaction of the accelerated particles as well as the amplification of
the turbulent magnetic field as due to streaming instability. The latter does
in turn affect the maximum achievable momentum and thereby the acceleration
process itself, in a chain of causality which is typical of non-linear systems.
Here we provide a technical description of two of these kinetic approaches and
show that they basically lead to the same conclusions. In particular we discuss
the effects of shock modification on the spectral shape of the accelerated
particles, on the maximum momentum, on the thermodynamic properties of the
background fluid and on the escaping and advected fluxes of accelerated
particles.Comment: 22 pages, 7 figures, accepted for publication in MNRA
FlashCam: a fully-digital camera for the medium-sized telescopes of the Cherenkov Telescope Array
The FlashCam group is currently preparing photomultiplier-tube based cameras
proposed for the medium-sized telescopes (MST) of the Cherenkov Telescope Array
(CTA). The cameras are designed around the FlashCam readout concept which is
the first fully-digital readout system for Cherenkov cameras, based on
commercial FADCs and FPGAs as key components for the front-end electronics
modules and a high performance camera server as back-end. This contribution
describes the progress of the full-scale FlashCam camera prototype currently
under construction, as well as performance results also obtained with earlier
demonstrator setups. Plans towards the production and implementation of
FlashCams on site are also briefly presented.Comment: 8 pages, 6 figures. In Proceedings of the 34th International Cosmic
Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions
at arXiv:1508.0589
Performance Verification of the FlashCam Prototype Camera for the Cherenkov Telescope Array
The Cherenkov Telescope Array (CTA) is a future gamma-ray observatory that is
planned to significantly improve upon the sensitivity and precision of the
current generation of Cherenkov telescopes. The observatory will consist of
several dozens of telescopes with different sizes and equipped with different
types of cameras. Of these, the FlashCam camera system is the first to
implement a fully digital signal processing chain which allows for a traceable,
configurable trigger scheme and flexible signal reconstruction. As of autumn
2016, a prototype FlashCam camera for the medium-sized telescopes of CTA nears
completion. First results of the ongoing system tests demonstrate that the
signal chain and the readout system surpass CTA requirements. The stability of
the system is shown using long-term temperature cycling.Comment: 5 pages, 13 figures, Proceedings of the 9th International Workshop on
Ring Imaging Cherenkov Detectors (RICH 2016), Lake Bled, Sloveni
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